They can be activated or inactivated by ligands, and are ideal candidates for therapeutic targeting. , circumventing the adverse effects that estrogen induces in men and women through ER? The PI's preliminary data supports the existence of three critical mechanisms whereby ER? This project takes advantage of the skills of the Center for Nuclear Receptors and Cell Signaling to provide a detailed understanding of ER?'s role and potential in colon cancer prevention and treatment.Elucidating the mechanism of immune suppression by SPRYSEC effectors from potato cyst nematodes Diaz Granados , A. Remarkably, they are able to escape detection by the plant immune system, despite their size and the damage they cause to the host upon infection. These round worms manipulate plant cell morphology and physiology to establish sophisticated feeding structures.
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If indeed the diverse SPRYSEC effector family functions as versatile suppressors of immunity, the expansion of this family may reflect adaptations to diversification of plant immune receptors.
Therefore our results may provide insight into the basis for virulence of nematodes in plants.
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